A Cross-Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children

Researchers examined the relationship between metabolites and subclinical atherosclerosis among children by examining the associations of metabolites with carotid intima‐media thickness (cIMT) and arterial pulse wave velocity (PWV) in adolescents and their parents.

Data from two independent population‐based studies, Australian CheckPoint study and ALSPAC (The Avon Longitudinal Study of Parents and Children) from UK were used. These data suggest that in children circulating metabolites have no consistent association with cIMT and PWV once adjusted for body mass index and blood pressure. In their middle‐aged parents, suggestive evidence of metabolite associations with PWV were identified.