Amino acid profile in women with gestational diabetes mellitus treated with metformin or insulin

This study compared the effects of metformin and insulin treatments of gestational diabetes mellitus (GDM) on amino acid metabolism.

Total of 217 pregnant women diagnosed with GDM were randomized to two treatment groups and the amino acid profiles were determined using NMR spectroscopy at the time of diagnose of 30 gestational weeks (gw) and at 36 gw. Compared to insulin metformin caused a greater increase in serum alanine, isoleucine and lactate concentrations. Although the observed differences in amino acids levels were relatively small and not concerning, additional studies and follow-up data are required to ensure the safety of metformin use in pregnancy.