Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome

This randomized trial aimed to characterize the metabolic effects of the Mediterranean (MED) diet in order to determine whether the observed beneficial effects of MED diet can be solely contributed to high intakes of MUFAs, or whether other components of the MED diet have additional health effects.

The findings demonstrate that the MUFA component is responsible for reducing LDL subclasses and fractions, causing an antiatherogenic lipid profile, whereas the other components in the MED diet additionally decrease the larger triglyceride rich subclasses of very‐low‐density lipoprotein (VLDL), resulting in favorable health effects.