Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome

In this first GWAS carried out in a Mediterranean population composed of subjects with metabolic syndrome in Spain, researchers confirmed the large contribution of the FASD1 gene cluster on chromosome 11 on total serum omega-3 PUFA, specifically DHA.

In addition, they observed consistent interaction between sex and adherence to Mediterranean diet.