A cross-sectional study in a sample of 3,048 adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort determined a disrupted metabolic profile of non-alcoholic fatty liver disease (NAFLD).

Consistent associations were observed between three different NAFLD indicators and an adverse lipoprotein and lipid profile in a large population of apparently healthy adolescents, aged 17 years. These results highlight the possibility that NAFLD at this young age might already have adverse consequences that can further increase the risk of future diabetes and cardiovascular disease.