Relationship between gut microbiota and circulating metabolites in population-based cohorts

This study aimed to examine the impact of gut microbiota on circulating metabolites measured by Nightingale's NMR technology.

Detailed metabolic profiles were assessed in 2,309 individuals from the Rotterdam Study and the LifeLines-DEEP cohort in whom gut microbiota was profiled using 16S rRNA gene sequencing. The study revealed association of 32 microbial families and genera with very-low-density and high-density lipoprotein subclasses, serum lipid measures, glycolysis-related metabolites, amino acids, and acute phase reaction markers. These observations provide novel insights into the role of microbiota in host metabolism and, most importantly, support the potential of gut microbiota as a target for therapeutic and preventive interventions.