Disease-wide association plots

Manhattan-like disease-wide association plot visualizations showing the hazard/odds ratios of metabolic biomarkers with 3-character ICD-10 endpoints in the UK Biobank. Significant associations are displayed as filled points, non-significant ones as hollow points.

Each biomarker was corrected for spectrometer and analyzed for association with a 3-character ICD-10 endpoint using logistic regression (prevalent endpoints) or Cox regression (incident and mortality endpoints) adjusted for sex, UK Biobank assessment center, and age (age was used as the timescale in Cox regression). For sex-specific diseases, the association analyses were performed in a subset containing only the specific sex, without the inclusion of sex as a covariate.

Please specify the input and click "Generate plot".