Our technology measures metabolomic biomarkers from human blood and urine and is built on three core principles: absolute quantification with high accuracy and precision, coverage of core metabolic functions, and population-scale throughput and cost-effectiveness.
We provide absolute concentrations of metabolite levels so you can easily compare results to other studies. Our method has been calibrated against global standards and references, which means that the values we provide are comparable to other calibrated methods, like traditional clinical chemistry. For our 39 validated blood biomarkers, you can replace clinical measurements entirely with Nightingale Health.
Our panel offers a comprehensive selection of metabolites spanning multiple pathways from one sample in one measurement. The metabolic pathways and functions include detailed lipids, insulin sensitivity, dietary intake, chronic inflammation, fluid balance, kidney function, and more. Furthermore, our large biobank datasets have shown the diverse ways in which these biomarkers are associated with a wide range of human diseases and traits.
With complete public datasets including UK Biobank and Estonian Biobank, Nightingale Health is the only omics technology that can be done on entire cohorts and populations. This means that every sample analyzed can be studied in the context of hundreds of thousands of others, enabling more robust and impactful research and interpretation.
How we measure metabolites
Nightingale Health's biomarker analysis technology is based on nuclear magnetic resonance (NMR) spectroscopy coupled with our proprietary algorithms to quantify over 200 biomarkers in absolute units from a single blood sample. Nightingale Health's platform is the first and currently the only truly large-scale metabolic biomarker profiling platform that also provides multiple clinically validated biomarkers.
Nightingale Health is committed to achieving high quality in all its services. Quality and compliance with all applicable regulatory and customer requirements underline all our operations.
Certified quality management system
Nightingale Health operates under a certified quality management system in accordance with EN ISO 13485:2016 and SFS-EN ISO/IEC 17025. All operations and processes involved in the analysis service fall under the QMS.
Nightingale Health measures all blood samples with a CE-marked IVD device. This means that samples are measured using the CE-marked IVD device that is used for the measurement of clinical samples for customers requiring the most stringent quality assurance.
External quality assurance
Nightingale Health participates in UK NEQAS, WEQAS and Labquality external quality assurance programmes to monitor the measurement quality between Nightingale Health and other laboratories.
Certified information security management system
Nightingale Health has an ISO/IEC 27001 certified Information Security Management System. ISO/IEC 27001 is a globally recognized standard for information security management systems. With the Information Security Management System, Nightingale Health ensures that it maintains appropriate measures to secure data, products, and services. This information security certification also shows Nightingale Health's overall dedication to data security and commitment to continuously develop information security within the company.
Nightingale Health operates under a certified quality management system in accordance with EN ISO 13485:2016 and SFS-EN ISO/IEC 17025, and blood samples are measured with a CE-marked IVD device. Analytical performance for the CE-marked analytes is demonstrated according to CLIA's US FDA recognized consensus standards, and the CE-marked analytes are calibrated to the standard reference materials, if available, provided by the National Institute of Standards and Technology (NIST).