Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

This study investigated the molecular pathways connecting potentially regulatory CpG sites to the associated disease or lifestyle factors, researchers conducted a multi-omics association study including 225 NMR-based lipid and metabolite measures in blood.

Results report 138 multi-omics associations at these CpG sites, including diabetes biomarkers at the diabetes-associated TXNIP locus, and smoking-specific metabolites and proteins at multiple smoking-associated loci, including AHRR.