Delayed postprandial TAG peak after intake of SFA compared with PUFA in subjects with and without familial hypercholesterolaemia: a randomised controlled trial

In this study, researchers investigated the postprandial response of TAG and lipid sub-classes after consumption of high-fat meals with different fat quality in subjects with familial hypercholesterolaemia (FH) compared with normolipidaemic controls.

In both FH and control subjects, the level of TAG and the largest VLDL sub-classes peaked at 2 h after intake of PUFA and at 4 h after intake of SFA. No significant differences were found in TAG levels between meals or between groups. The distinct TAG peaks may reflect differences in the postprandial lipid metabolism after intake of fatty acids with different chain lengths and degrees of saturation.