Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation

Insulin resistance has deleterious effects on cardiometabolic disease.

In this paper, researchers used Mendelian randomization analyses to clarify the causal relationships of insulin resistance (IR) on circulating blood-based metabolites. Results provide evidence evidence that IR causally affects each individual BCAA and inflammation, impling that BCAA metabolism lies on a causal pathway from adiposity and IR to type 2 diabetes.