Metabolomics
Unlock high-resolution metabolomic profiling to capture precise, quantitative insights into systemic metabolism. When combined with proteomics, metabolomics enables deeper biological discovery and seamless integration of biomarker data across cohorts.
Metabolomics for population health studies
Metabolomics provides a comprehensive and quantitative view of lipids and small molecules in blood and urine samples, reflecting both current health status and future disease risk across populations. These biomarker signals enable the detection of early biological changes across the lifecourse, supporting insights into disease development and progression.
Many risk factors, genes, and diseases are characterized by distinct metabolic signatures. Such metabolic profiles are well suited for analysis using Nightingale Health’s metabolomics data and can be seamlessly combined across multiple cohorts. Because the biomarker data is measured in absolute concentrations and is free from batch effects, it supports robust analysis of samples collected at multiple time points and across a wide range of study designs.
Nightingale Health’s technology
Metabolomics for powerful research insights
Nightingale Health’s metabolomics platform is based on nuclear magnetic resonance (NMR) spectroscopy, automated for high-throughput blood sample profiling with clinical-grade consistency. Proprietary algorithms quantify 250+ metabolic measures from each blood sample, providing both established and emerging biomarkers relevant across all areas of medicine.
Our metabolomics service has been widely proven to deliver accuracy and consistency for studies of any size. Our biomarker panel, CoreMetabolomics, captures numerous metabolic pathways, including detailed lipid metabolism, insulin sensitivity, inflammation, kidney and liver function, as well as energy balance.
At the population scale, such as in the UK Biobank’s 500,000 participants, metabolomic profiling enables researchers to explore metabolic determinants of health with unprecedented statistical power and consistency. This establishes metabolomics as a foundational tool in epidemiology, biomarker discovery, precision medicine, and multiomics-integrated research.
Kickstart your research with CoreMetabolomics
Designed for research needs
Metabolomics is where our story began, and it remains at the core of what we do today.
Our CoreMetabolomics service for blood measures lipoprotein lipids in great detail, fatty acids, amino acids, glycolysis markers, and inflammatory proteins, delivering comprehensive molecular insights reproducibly and cost-effectively.
These biomarkers are associated with diverse aspects of human health, spanning cardiometabolic disease, brain health, and susceptibility to infections. They also reflect the exposome, including smoking, diet, and medications, and provide robust baseline data to support your study.
Explore CoreMetabolomics by sample types
Choose from our venous blood, dried blood, and urine analysis collection options.
Venous blood analysis
Boost your research with high-throughput, quantitative biomarker profiling.
Dried blood analysis + Nightingale Kit
Perform multiomics research anywhere with reliable self-collected blood samples.
Urine analysis
Discover new insights into dietary impact, kidney function, and disease mechanisms.
Metabolomics + Proteomics
Two complementary ’omics layers in one workflow
Metabolomics offers a downstream readout of metabolic activity, while proteomics captures upstream signaling and pathway regulation. When these datasets are analyzed together, metabolic outputs can be linked directly to the proteins that drive or reflect them. This combined perspective can increase sensitivity to detect early biological changes, strengthen mechanistic interpretation, and enhance comparability across cohorts and time points.
Cohorts using Nightingale Health's data
Nightingale Health multiomics research service provides comprehensive biomarker profiling for cohorts of any size. Because our metabolomics platform has been used to profile all 500,000 participants in the UK Biobank, you can directly combine insights from your study with data on the same biomarkers from the world’s largest health research dataset.