Publications

Nightingale’s biomarker analysis platform is routinely used in world-class epidemiological and genetic studies. There are over 450 publications that have applied our method.

All

Metabolic risk factors

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

Nightingale's blood biomarkers were used for prediction of severe pneumonia and COVID-19 hospitalisation in 105,146 plasma samples collected in the UK Biobank during 2007-2010.

Julkunen et al, ELife 2021

Metabolic risk factors

Metabolomic profiles predict individual multidisease outcomes

Buergel, T., Steinfeldt, J., Ruyoga, G. et al. Nat Med (2022)

Neurological diseases

Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

Zhang et al. BMC Med. 2022 Aug 15;20(1):252.

Metabolic risk factors

Metabolite and lipid biomarkers associated with intraocular pressure and inner retinal morphology: results from the UK Biobank

Pasquale et al. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2291

Cardiovascular diseases

Circulating metabolites associated with incident myocardial infarction and stroke: A prospective cohort study of 90 438 participants

Guo et al. Journal of Neurochemistry, 162, 371– 384

Drug development

Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses

Ibi et al. 2022. Journal of Lipid Research, Volume 63, Issue 5, 100193

Bioinformatics

Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses

Middleton et al. 2022. Nucleic Acids Research, Volume 50, Issue 8, 6 May 2022, Pages 4289–4301

Cardiovascular diseases

The metabolic signature of cardiovascular disease and arterial calcification in patients with chronic kidney disease

Sørensen et al. Atherosclerosis. 2022 Jun;350:109-118

Bioinformatics

Sex Differences in the Metabolome of Alzheimer's Disease Progression

Zarzar et al. Front Radiol. 2022;2:782864.

Gut microbiota

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

Talmor-Barkan et al. Nat Med. 2022 Feb;28(2):295-302

Metabolic risk factors

Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue

Boone et al. American Journal of Epidemiology, Volume 191, Issue 5, May 2022, Pages 886–899

Neurological diseases

Profiling the metabolome of patients with dementia in the UK Biobank

Liu et al. Alzheimer's Dement., 17: e056147

T2D

Circulating metabolic biomarkers are consistently associated with incident type 2 diabetes in Asian and European populations – a metabolomics analysis in five prospective cohorts

Hoong Seah et al, medRxiv 2021

T1D

Urinary metabolite profiling and risk of progression of diabetic nephropathy in 2670 individuals with type 1 diabetes

Mutter et al, Diabetologia 2021

T2D

Predictive value of circulating NMR metabolic biomarkers for type 2 diabetes risk in the UK Biobank study

Bragg et al, medRxiv 2021

Human genetics

Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

Li-Gao et al. Diabetes. 2021 Dec;70(12):2932-2946

T2D

Plasma fatty acids and the risk of vascular disease and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE study

Harris et al. Diabetologia 2020

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