Genetics

Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses

L. Middleton et. al, Nucleic Acids Research, 2022
Ageing & dementia

Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1H NMR Spectroscopy Results From the UK Biobank

L. Pasquale et. al, Investigative Opthalmology & Visual Science, 2023
Cardiovascular disease

High density lipoprotein subfractions and extent of coronary atherosclerotic lesions: From the cordioprev study

S. De La Cruz-Ares et. al, Clinica Chimica Acta, 2022
Maternal & child health

Maternal inflammatory and omega-3 fatty acid pathways mediate the association between socioeconomic disadvantage and childhood cognition

W. Marx et. al, Brain, Behavior, and Immunity, 2021
Cardiovascular disease

Decreasing severity of obesity from early to late adolescence and young adulthood associates with longitudinal metabolomic changes implicated in lower cardiometabolic disease risk

T. Mansell et. al, International Journal of Obesity, 2022
Diabetes, Maternal & child health

Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low- and High-Risk Women Living in the UK

H. Fuller et. al, The Journal of Nutrition, 2022
Diabetes

The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)

L. Corbin et. al, Diabetologia, 2023
Inflammation & immunity, Lung disease, Genetics

Circulating Polyunsaturated Fatty Acids and COVID-19: A Prospective Cohort Study and Mendelian Randomization Analysis

Y. Sun et. al, Frontiers in Medicine, 2022
Cardiovascular disease, Genetics

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants

M. Borges et. al, BMC Medicine, 2022
Cardiovascular disease, Ageing & dementia

Metabolic associations with stroke, dementia, and imaging markers of cerebral small vessel disease: a comprehensive metabolomics study

E. Harshfield et. al, 2022
Genetics, Ageing & dementia

Effects of genetic liability to Alzheimer’s disease on circulating metabolites across the life course

Genetics

Fifty-one novel and replicated GWAS loci for polyunsaturated and monounsaturated fatty acids in 124,024 Europeans

M. Francis et. al, 2022
Methods, Genetics

Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures

V. Karageorgiou et. al, eLife, 2023
Ageing & dementia

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

E. Macdonald-Dunlop et. al, Aging, 2022
Genetics

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

C. Smith et. al, eLife, 2022