Ageing & dementia, Genetics

Heterogeneous metabolomic aging across the same age and prediction of health outcome

X. Jia et. al, 2024
Lung disease

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

W. Hu et. al, BMC Medicine, 2024
Medicines & trials

Impact of Distinct Antiandrogen Exposures on the Plasma Metabolome in Feminizing Gender-affirming Hormone Therapy

R. Shepherd et. al, The Journal of Clinical Endocrinology & Metabolism, 2024
Risk prediction, Liver disease

Machine-learning–based plasma metabolomic profiles for predicting long-term complications of cirrhosis

C. Guo et. al, Hepatology, 2024
Obesity & bodyweight

Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health

S. Lockhart et. al, 2024
Methods

A machine learning algorithm based on circulating metabolic biomarkers offers improved predictions of neurological diseases

L. Han et. al, Clinica Chimica Acta, 2024
Psychiatric disorders

Longitudinal Trajectories of Plasma Polyunsaturated Fatty Acids and Associations With Psychosis Spectrum Outcomes in Early Adulthood

D. Mongan et. al, Biological Psychiatry, 2024
Obesity & bodyweight, Cardiovascular disease, Diabetes

Unsupervised clustering identified clinically relevant metabolic syndrome endotypes in UK and Taiwan Biobanks

A. Lim et. al, iScience, 2024
Ageing & dementia, Obesity & bodyweight

Influence of age and sex on longitudinal metabolic profiles and body weight trajectories in the UK Biobank

V. Mäkinen et. al, International Journal of Epidemiology, 2024
Cancer, Obesity & bodyweight

Adiposity, metabolites and endometrial cancer risk: Mendelian randomization and Observational analyses

M. Lee et. al, 2024
Inflammation & immunity

The plasma metabolome of systemic juvenile idiopathic arthritis is different to non-JIA controls and partially explained by chronic inflammation

J. Kwon et. al, 2024
Cardiovascular disease

The role of genetically-influenced phospholipid transfer protein activity in lipoprotein metabolism and coronary artery disease

L. Ao et. al, Journal of Clinical Lipidology, 2024
Maternal & child health, Diabetes

Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases

M. Taeubert et. al, 2024
Diabetes, Maternal & child health

Associations of birth weight, plasma metabolome in adulthood and risk of type 2 diabetes

W. Wang et. al, Diabetes/Metabolism Research and Reviews, 2024
Cardiovascular disease

Gene expression profiling in elderly patients with familial hypercholesterolemia with and without coronary heart disease

T. Melnes et. al, Atherosclerosis, 2024