Medicines & trials

Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome

A. Nummela et. al, European Journal of Anaesthesiology, 2021
Obesity & bodyweight

Mitochondrial bioenergetic pathways in blood leukocyte transcriptome decrease after intensive weight loss but are rescued following weight regain in female physique athletes

H. Sarin et. al, The FASEB Journal, 2021
Genetics, Methods

A Computationally Efficient Bayesian Seemingly Unrelated Regressions Model for High-Dimensional Quantitative Trait Loci Discovery

L. Bottolo et. al, Journal of the Royal Statistical Society Series C: Applied Statistics, 2021
Exposome & nutrition

NMR Metabolite Profiles in Male Meat-Eaters, Fish-Eaters, Vegetarians and Vegans, and Comparison with MS Metabolite Profiles

J. Schmidt et. al, Metabolites, 2021
Genetics

Novel protein-altering variants associated with serum apolipoprotein and lipid levels

Genetics

Assessing the contribution of rare-to-common protein-coding variants to circulating metabolic biomarker levels via 412,394 UK Biobank exome sequences

A. Nag et. al, 2021
Diabetes, Risk prediction

Predictive value of circulating NMR metabolic biomarkers for type 2 diabetes risk in the UK Biobank study

F. Bragg et. al, BMC Medicine, 2022
Inflammation & immunity

Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk

G. Robinson et. al, Metabolites, 2021
Cardiovascular disease

Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease: Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts

E. Tikkanen et. al, Journal of the American Heart Association, 2021
Maternal & child health

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis

T. Richardson et. al, International Journal of Epidemiology, 2021
Ageing & dementia

Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease

J. Lord et. al, Proceedings of the National Academy of Sciences, 2021
Genetics

An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers

S. Fang et. al, 2021
Cardiovascular disease

Very Low-Density Lipoprotein Cholesterol May Mediate a Substantial Component of the Effect of Obesity on Myocardial Infarction Risk: The Copenhagen General Population Study

M. Johansen et. al, Clinical Chemistry, 2020
Cardiovascular disease

Towards early risk biomarkers: serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood

X. Ojanen et. al, eBioMedicine, 2021
Cardiovascular disease

The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions. The Cardiovascular Risk in Young Finns Study

P. Kresanov et. al, Free Radical Biology and Medicine, 2020