Kidney disease

#5650 METABOLIC BLOOD BIOMARKER PROFILING FOR CHRONIC KIDNEY DISEASE PREDICTION – EVIDENCE FROM 275,000 INDIVIDUALS IN THE UK BIOBANK

H. Julkunen et. al, Nephrology Dialysis Transplantation, 2023
Inflammation & immunity

Mendelian Randomization Analysis Reveals Metabolite and Inflammatory Factor Associations with Inflammatory Bowel Disease

Z. Long et. al, 2023
Exposome & nutrition, Methods

Refinement of a published gene-physical activity interaction impacting HDL-cholesterol: role of sex and lipoprotein subfractions

K. Westerman et. al, 2024
Exposome & nutrition

Mild processing and addition of milk fat globule membrane in infant formula may better mimic intragastric behavior of human milk: A proof of concept trial in healthy males

J. Roelofs et. al, Food Hydrocolloids, 2024
Maternal & child health

Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study

A. Elhakeem et. al, 2024
Cancer

Circulating metabolome landscape in Lynch syndrome

T. Jokela et. al, Cancer & Metabolism, 2024
Ageing & dementia, Risk prediction, Mortality & multi-morbidity

Metabolomic Age (MileAge) predicts health and lifespan: a comparison of multiple machine learning algorithms

J. Mutz et. al, 2024
Cancer

Causal association of smoking, blood lipids, and bladder cancer: Insights from a multivariable and mediation mendelian randomization investigation

H. Wei et. al, Journal of Cancer, 2024
Diabetes, Genetics

Branched‐chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis

J. Mosley et. al, Obesity, 2024
Ageing & dementia, Genetics

Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease

H. Compton et. al, Scientific Reports, 2024
Ageing & dementia, Exposome & nutrition, Psychiatric disorders

Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders

H. Xu et. al, 2023
Cancer, Exposome & nutrition

Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: a population-based cohort study in UK Biobank

Y. Zhang et. al, 2024
Maternal & child health, Ageing & dementia

The impact of reproductive factors on the metabolic profile of females from menarche to menopause

G. Clayton et. al, Nature Communications, 2024
Risk prediction, Methods, Liver disease

Machine learning across multiple imaging and biomarker modalities in the UK Biobank improves genetic discovery for liver fat accumulation

H. Somineni et. al, 2024
Exposome & nutrition, Cardiovascular disease

Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study

Q. Wang et. al, Journal of Stroke, 2023